{"id":85105,"date":"2026-07-10T15:58:56","date_gmt":"2026-07-10T15:58:56","guid":{"rendered":"https:\/\/www.cofb.org\/?p=85105"},"modified":"2026-07-13T16:02:09","modified_gmt":"2026-07-13T16:02:09","slug":"el-programa-de-formacio-continuada-2025-2026-tanca-el-curs-amb-el-forum-dermoexpert-epigenetica-noves-bases-per-a-la-dermocosmetica","status":"publish","type":"post","link":"https:\/\/www.cofb.org\/es\/2026\/07\/10\/el-programa-de-formacio-continuada-2025-2026-tanca-el-curs-amb-el-forum-dermoexpert-epigenetica-noves-bases-per-a-la-dermocosmetica\/","title":{"rendered":"El Programa de Formaci\u00f3n Continua 2025-2026 cierra el curso con el Foro Dermoexpert \u201cEpigen\u00e9tica: nuevas bases para la dermocosm\u00e9tica\u201d"},"content":{"rendered":"

El pasado 18 de junio, el Col\u00b7legi de Farmac\u00e8utics de Barcelona (COFB) <\/strong>organiz\u00f3 el \u00faltimo Foro Dermoexpert \u201cEpigen\u00e9tica: nuevas bases para la dermocosm\u00e9tica\u201d<\/strong>, con el patrocinio deHD Cosmetic Efficiency<\/a><\/strong>. El Foro fue impartido por Regina Pall\u00e1s<\/strong>, farmac\u00e9utica y directora de I+D de Dermogalenic Experts; Jose Lu\u00eds Mullor<\/strong>, bi\u00f3logo, doctor en bioqu\u00edmica y biolog\u00eda molecular y director cient\u00edfico y CEO de Bionos Biotech; y Miquel Serra<\/strong>, farmac\u00e9utico comunitario. La vocal de Dermofarmacia y Productos Sanitarios del COFB, Marta Alcalde<\/strong>, coordin\u00f3 la sesi\u00f3n dirigida a farmac\u00e9uticos de farmacia comunitaria.<\/p>\n\n\n\n

\"D'esquerra<\/a>
De izquierda a derecha: Marta Alcalde, Regina Pall\u00e0s y Miquel Serra. <\/figcaption><\/figure>\n\n\n\n

Los objetivos <\/strong>del Foro Dermoexpert fueron conocer los fundamentos cient\u00edficos de la epigen\u00e9tica<\/strong>, entender los mecanismos de acci\u00f3n de las mol\u00e9culas con actividad epigen\u00e9tica en la dermis<\/strong>, saber cu\u00e1l es el proceso de investigaci\u00f3n y elaboraci\u00f3n de estudios de eficacia<\/strong> y revisar la aplicaci\u00f3n pr\u00e1ctica de estos nuevos activos cosm\u00e9ticos<\/strong>.<\/p>\n\n\n\n

La vocal de Dermofarmacia y Productos Sanitarios del COFB, Marta Alcalde<\/strong>, destac\u00f3 que con esta formaci\u00f3n se cierra el ciclo de formaciones del Programa de Formaci\u00f3n Continuada 2025-2026<\/strong>. La formaci\u00f3n puso el foco al conocer c\u00f3mo la epigen\u00e9tica puede servir como base para crear nuevos activos cosm\u00e9ticos<\/strong> que puedan actuar en temas de envejecimiento cut\u00e1neo y saber en qu\u00e9 se basa esta ciencia\u201d, indic\u00f3 Alcalde.<\/p>\n\n\n\n

A continuaci\u00f3n, intervino Regina Pall\u00e1s<\/strong> que profundiz\u00f3 en la epigen\u00e9tica, sus fundamentos y la evidencia cient\u00edfica. La farmac\u00e9utica describi\u00f3 la epigen\u00e9tica<\/strong> c\u00f3mo "el estudio sobre c\u00f3mo los factores externos interact\u00faan con nuestros genes, modificando su expresi\u00f3n sin alterar la secuencia del ADN".<\/strong> Seg\u00fan detall\u00f3, lo hacen a trav\u00e9s de mecanismos moleculares que funcionan como interruptores a trav\u00e9s de los cuales los genes se activan o desactivan<\/strong>. Sin embargo, introdujo el concepto de exposoma<\/strong>, que \u201cengloba la totalidad de las exposiciones ambientales y personales a lo largo de la vida<\/strong>\u201d. As\u00ed pues, "cada exposici\u00f3n puede dejar una huella epigen\u00e9tica que modifica la expresi\u00f3n g\u00e9nica"<\/strong>, aunque "la exposoma no cambia la secuencia de nuestro ADN, pero s\u00ed puede modificar c\u00f3mo se expresan nuestros genes".<\/strong> En este contexto, asegur\u00f3 que \u201cla ciencia cosm\u00e9tica encuentra en la epigen\u00e9tica un gran potencial para desarrollar nuevas formulaciones con activos que regulan epigen\u00e9ticamente la expresi\u00f3n de aquellos genes de inter\u00e9s<\/strong>". Para mostrarlo, Pall\u00e1s comparti\u00f3 el caso de dos personas gemelas, con el mismo ADN, que muestran patrones de envejecimiento diferentes porque "la exposoma les ha dejado una huella epigen\u00e9ticamente diferente".<\/p>\n\n\n\n

Senescencia celular y envejecimiento de la piel<\/strong><\/h2>\n\n\n\n

En relaci\u00f3n con el envejecimiento de la piel, la farmac\u00e9utica hizo referencia a la senescencia celular<\/strong>, \u201cun estado de detenci\u00f3n del ciclo celular irreversible, acompa\u00f1ado de cambios fenot\u00edpicos y secretorios (SASP)<\/strong>\u201d Algunos de los factores que pueden desencadenar que las c\u00e9lulas entren en un estado de senescencia son el da\u00f1o en el ADN, el estr\u00e9s oxidativo o el deterioro de la autofagia.<\/p>\n\n\n\n

\"Regina<\/a>
Regina Pall\u00e0s en un momento de su intervenci\u00f3n. <\/figcaption><\/figure>\n\n\n\n

Ahora bien, Regina Pall\u00e0s indic\u00f3 que la modulaci\u00f3n de la epigen\u00e9tica<\/strong> ofrece v\u00edas para atenuar las se\u00f1ales pro-senescentes y restaurar un comportamiento celular m\u00e1s juvenil, sin eliminar el mecanismo de seguridad antitumoral. As\u00ed pues, "la ciencia cosm\u00e9tica encuentra en la epigen\u00e9tica una v\u00eda para desarrollar activos con mecanismos de acci\u00f3n precisos y medibles".<\/strong><\/p>\n\n\n\n

Para cerrar su exposici\u00f3n, hizo referencia al proyecto CDTI<\/strong> que se centra en el desarrollo de c\u00f3cteles de activos con mecanismos de acci\u00f3n sobre un microARN del envejecimiento cut\u00e1neo.<\/p>\n\n\n\n

Bionos, innovaci\u00f3n aplicada<\/strong><\/h2>\n\n\n\n

Seguidamente, Jose Lu\u00eds Mullor<\/strong>, bi\u00f3logo y doctor en bioqu\u00edmica y biolog\u00eda molecular, expuso la actividad de Bionos Biotech<\/strong>, uno instituto de investigaci\u00f3n del Hospital Universitario y Polit\u00e9cnico La Fe de Valencia<\/strong>. Mullor destac\u00f3 el modelo de colaboraci\u00f3n de Bionos con Dermogalenic Experts, \u201cun modelo de trabajo que transforma la hip\u00f3tesis cient\u00edfica en activos cosm\u00e9ticos con evidencia real\u201d y que se basa en tres palancas: la formulaci\u00f3n estrat\u00e9gica de preguntas, la ejecuci\u00f3n rigurosa con metodolog\u00eda y la traducci\u00f3n en argumentario y claim<\/em>. De esta forma, el resultado son productos con eficacia demostrada que el farmac\u00e9utico puede argumentar con fundamento cient\u00edfico real<\/strong>.<\/p>\n\n\n\n

\"Jose<\/a>
Jose Lu\u00eds Mullor durante su presentaci\u00f3n. <\/figcaption><\/figure>\n\n\n\n

El bi\u00f3logo coment\u00f3 que el camino para pasar de una hip\u00f3tesis cient\u00edfica a un producto dermocosm\u00e9tico defendible requiere un protocolo de validaci\u00f3n estructurado, basado en la hip\u00f3tesis y el dise\u00f1o, la validaci\u00f3n in vitro<\/em>, la validaci\u00f3n in vivo<\/em>, la formulaci\u00f3n y el claim, <\/em>avalado con datos, es decir, con evidencia cient\u00edfica real. A lo largo de su exposici\u00f3n, Mullor desgran\u00f3 la metodolog\u00eda de estudio<\/strong> (el modelo experimental, el dise\u00f1o del estudio y la tecnolog\u00eda de an\u00e1lisis) y los resultados del estudio<\/strong> (reproductibilidad del efecto, regulaci\u00f3n epigen\u00e9tica e impacto biol\u00f3gico).<\/p>\n\n\n\n

Del laboratorio al mostrador de la farmacia<\/strong><\/h2>\n\n\n\n

Por \u00faltimo, intervino el farmac\u00e9utico comunitario Miquel Serra <\/strong>para explicar el cambio de enfoque en la recomendaci\u00f3n de un producto. En ese o\u00eddo, dijo que "el cambio no est\u00e1 s\u00f3lo en el producto, est\u00e1 en el punto de partida y en c\u00f3mo se interpreta al paciente desde la farmacia comunitaria"<\/strong>. Serra indic\u00f3 que un farmac\u00e9utico debe identificar la necesidad real del paciente, traducir el mecanismo en un beneficio claro, adaptar la recomendaci\u00f3n al contexto real y priorizar lo necesario para obtener un resultado. A su vez, recomend\u00f3 traducir la innovaci\u00f3n al lenguaje del cliente <\/strong>porque "el farmac\u00e9utico hace cada d\u00eda lo que ning\u00fan investigador puede hacer, que es tomar conceptos complejos y traducirlos de forma clara y \u00fatil para el paciente".<\/strong><\/p>\n\n\n\n

\"Miquel<\/a>
Miquel Serra en un momento de su exposici\u00f3n.<\/figcaption><\/figure>\n\n\n\n

Por otra parte, diferenci\u00f3 la interpretaci\u00f3n de la piel del paciente en tres niveles para identificar la necesidad real y decidir la recomendaci\u00f3n m\u00e1s adecuada. As\u00ed, hizo referencia a la demanda expl\u00edcita, la lectura profesional y el mecanismo subyacente. El farmac\u00e9utico destac\u00f3 el rol del farmac\u00e9utico comunitario como referente que aporta "claridad, seguridad y resultados reales"<\/strong>.<\/p>\n\n\n\n

Para cerrar la sesi\u00f3n, el farmac\u00e9utico comparti\u00f3 una \u00faltima reflexi\u00f3n en torno a la epigen\u00e9tica, que "nos ha ense\u00f1ado que el destino gen\u00e9tico no es una sentencia porque el entorno y las intervenciones activas pueden modificar c\u00f3mo y cu\u00e1ndo envejecen nuestras c\u00e9lulas".<\/strong><\/p>\n\n\n\n

Con el patrocinio de:<\/strong><\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

El pasado 18 de junio, el Colegio de Farmac\u00e9uticos de Barcelona (COFB) organiz\u00f3 el \u00faltimo Foro Dermoexpert \u201cEpigen\u00e9tica: nuevas bases para la dermocosm\u00e9tica\u201d, con el patrocinio de HD Cosmetic Efficiency. El F\u00f3rum fue impartido por Regina Pall\u00e1s, farmac\u00e9utica y directora de I+D de Dermogalenic Experts; Jose Lu\u00eds Mullor, bi\u00f3logo, [\u2026]<\/p>","protected":false},"author":3,"featured_media":85109,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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