{"id":85105,"date":"2026-07-10T15:58:56","date_gmt":"2026-07-10T15:58:56","guid":{"rendered":"https:\/\/www.cofb.org\/?p=85105"},"modified":"2026-07-13T16:02:09","modified_gmt":"2026-07-13T16:02:09","slug":"el-programa-de-formacio-continuada-2025-2026-tanca-el-curs-amb-el-forum-dermoexpert-epigenetica-noves-bases-per-a-la-dermocosmetica","status":"publish","type":"post","link":"https:\/\/www.cofb.org\/ca\/2026\/07\/10\/el-programa-de-formacio-continuada-2025-2026-tanca-el-curs-amb-el-forum-dermoexpert-epigenetica-noves-bases-per-a-la-dermocosmetica\/","title":{"rendered":"El Programa de Formaci\u00f3 Continuada 2025-2026 tanca el curs amb el F\u00f2rum Dermoexpert \u201cEpigen\u00e8tica: noves bases per a la dermocosm\u00e8tica\u201d"},"content":{"rendered":"\n

El passat 18 de juny, el Col\u00b7legi de Farmac\u00e8utics de Barcelona (COFB) <\/strong>va organitzar el darrer F\u00f2rum Dermoexpert \u201cEpigen\u00e8tica: noves bases per a la dermocosm\u00e8tica\u201d<\/strong>, amb el patrocini d\u2019HD Cosmetic Efficiency<\/a><\/strong>. El F\u00f2rum va ser impartit per Regina Pall\u00e1s<\/strong>, farmac\u00e8utica i directora d\u2019I+D de Dermogalenic Experts; Jose Lu\u00eds Mullor<\/strong>, bi\u00f2leg, doctor en bioqu\u00edmica i biologia molecular i director cient\u00edfic i CEO de Bionos Biotech; i Miquel Serra<\/strong>, farmac\u00e8utic comunitari. La vocal de Dermofarm\u00e0cia i Productes Sanitaris del COFB, Marta Alcalde<\/strong>, va coordinar la sessi\u00f3 adre\u00e7ada a farmac\u00e8utics de farm\u00e0cia comunit\u00e0ria.<\/p>\n\n\n\n

\"D'esquerra<\/a>
D’esquerra a dreta: Marta Alcalde, Regina Pall\u00e0s i Miquel Serra. <\/figcaption><\/figure>\n\n\n\n

Els objectius <\/strong>del F\u00f2rum Dermoexpert van ser con\u00e8ixer els fonaments cient\u00edfics de l’epigen\u00e8tica<\/strong>, entendre els mecanismes d\u2019acci\u00f3 de les mol\u00e8cules amb activitat epigen\u00e8tica a la dermis<\/strong>, saber quin \u00e9s el proc\u00e9s d\u2019investigaci\u00f3 i d\u2019elaboraci\u00f3 d\u2019estudis d\u2019efic\u00e0cia<\/strong> i revisar l’aplicaci\u00f3 pr\u00e0ctica d’aquests nous actius cosm\u00e8tics<\/strong>.<\/p>\n\n\n\n

La vocal de Dermofarm\u00e0cia i Productes Sanitaris del COFB, Marta Alcalde<\/strong>, va destacar que amb aquesta formaci\u00f3 es tanca el cicle de formacions del Programa de Formaci\u00f3 Continuada 2025-2026<\/strong>. La formaci\u00f3 va posar el focus en con\u00e8ixer com l\u2019epigen\u00e8tica pot servir com a base per crear nous actius cosm\u00e8tics<\/strong> que puguin actuar en temes d\u2019envelliment cutani i saber en qu\u00e8 es basa aquesta ci\u00e8ncia\u201d, va indicar Alcalde.<\/p>\n\n\n\n

A continuaci\u00f3, va intervenir Regina Pall\u00e1s<\/strong> que va aprofundir en l\u2019epigen\u00e8tica, els seus fonaments i l\u2019evid\u00e8ncia cient\u00edfica. La farmac\u00e8utica va descriure l\u2019epigen\u00e8tica<\/strong> com \u201cl\u2019estudi sobre com els factors externs interactuen amb els nostres gens, modificant la seva expressi\u00f3 sense alterar la seq\u00fc\u00e8ncia de l\u2019ADN\u201d.<\/strong> Segons va detallar, ho fan a trav\u00e9s de mecanismes moleculars que funcionen com a interruptors a trav\u00e9s els quals els gens s\u2019activen o es desactiven<\/strong>. Tanmateix, va introduir el concepte d\u2019exposoma<\/strong>, que \u201cengloba la totalitat de les exposicions ambientals i personals al llarg de la vida<\/strong>\u201d. Aix\u00ed doncs, \u201ccada exposici\u00f3 pot deixar una petjada epigen\u00e8tica que modifica l\u2019expressi\u00f3 g\u00e8nica\u201d<\/strong>, tot i que \u201cl\u2019exposoma no canvia la seq\u00fc\u00e8ncia del nostre ADN, per\u00f2 s\u00ed pot modificar com s\u2019expressen els nostres gens\u201d.<\/strong> En aquest context, va assegurar que \u201cla ci\u00e8ncia cosm\u00e8tica troba en l\u2019epigen\u00e8tica un gran potencial per desenvolupar noves formulacions amb actius que regulen epigen\u00e8ticament l\u2019expressi\u00f3 d\u2019aquells gens d\u2019inter\u00e8s<\/strong>\u201d. Per mostrar-ho, Pall\u00e1s va compartir el cas de dues persones bessones, amb el mateix ADN, que mostren patrons d\u2019envelliment diferents perqu\u00e8 \u201cl\u2019exposoma els ha deixat una petjada epigen\u00e8ticament diferent\u201d.<\/p>\n\n\n\n

Senesc\u00e8ncia cel\u00b7lular i envelliment de la pell<\/strong><\/h2>\n\n\n\n

En relaci\u00f3 amb l\u2019envelliment de la pell, la farmac\u00e8utica va fer refer\u00e8ncia a la senesc\u00e8ncia cel\u00b7lular<\/strong>, \u201cun estat de detenci\u00f3 del cicle cel\u00b7lular irreversible, acompanyat de canvis fenot\u00edpics i secretoris (SASP)<\/strong>\u201d. Alguns dels factors que poden desencadenar que les c\u00e8l\u00b7lules entrin en un estat de senesc\u00e8ncia s\u00f3n el dany en l\u2019ADN, l\u2019estr\u00e8s oxidatiu o el deteriorament de l\u2019autof\u00e0gia.<\/p>\n\n\n\n

\"Regina<\/a>
Regina Pall\u00e0s en un moment de la seva intervenci\u00f3. <\/figcaption><\/figure>\n\n\n\n

Ara b\u00e9, Regina Pall\u00e0s va indicar que la modulaci\u00f3 de l\u2019epigen\u00e8tica<\/strong> ofereix vies per atenuar els senyals pro-senescents i restaurar un comportament cel\u00b7lular m\u00e9s juvenil, sense eliminar el mecanisme de seguretat antitumoral. Aix\u00ed doncs, \u201cla ci\u00e8ncia cosm\u00e8tica troba en l\u2019epigen\u00e8tica una via per desenvolupar actius amb mecanismes d\u2019acci\u00f3 precisos i mesurables\u201d.<\/strong><\/p>\n\n\n\n

Per tancar la seva exposici\u00f3, va fer refer\u00e8ncia al projecte CDTI<\/strong> que se centra en el desenvolupament de c\u00f2ctels d\u2019actius amb mecanismes d\u2019acci\u00f3 sobre un microARN de l\u2019envelliment cutani.<\/p>\n\n\n\n

Bionos, innovaci\u00f3 aplicada<\/strong><\/h2>\n\n\n\n

Seguidament, Jose Lu\u00eds Mullor<\/strong>, bi\u00f2leg i doctor en bioqu\u00edmica i biologia molecular, va exposar l\u2019activitat de Bionos Biotech<\/strong>, un institut d\u2019investigaci\u00f3 de l\u2019Hospital Universitari i Polit\u00e8cnic La Fe de Val\u00e8ncia<\/strong>. Mullor va destacar el model de col\u00b7laboraci\u00f3 de Bionos amb Dermogalenic Experts, \u201cun model de treball que transforma la hip\u00f2tesis cient\u00edfica en actius cosm\u00e8tics amb evid\u00e8ncia real\u201d i que es basa en tres palanques: la formulaci\u00f3 estrat\u00e8gica de preguntes, l\u2019execuci\u00f3 rigorosa amb metodologia i la traducci\u00f3 en argumentari i claim<\/em>. D\u2019aquesta manera, el resultat s\u00f3n productes amb efic\u00e0cia demostrada que el farmac\u00e8utic pot argumentar amb fondament cient\u00edfic real<\/strong>.<\/p>\n\n\n\n

\"Jose<\/a>
Jose Lu\u00eds Mullor durant la seva presentaci\u00f3. <\/figcaption><\/figure>\n\n\n\n

El bi\u00f2leg va comentar que el cam\u00ed per passar d\u2019una hip\u00f2tesi cient\u00edfica a un producte dermocosm\u00e8tic defensable requereix d\u2019un protocol de validaci\u00f3 estructurat, basat en la hip\u00f2tesi i el disseny, la validaci\u00f3 in vitro<\/em>, la validaci\u00f3 in vivo<\/em>, la formulaci\u00f3 i el claim, <\/em>avalat amb dades, \u00e9s a dir, amb evid\u00e8ncia cient\u00edfica real. Al llarg de la seva exposici\u00f3, Mullor va desgranar la metodologia d\u2019estudi<\/strong> (el model experimental, el disseny de l\u2019estudi i la tecnologia d\u2019an\u00e0lisi) i els resultats de l\u2019estudi<\/strong> (reproductibilitat de l\u2019efecte, regulaci\u00f3 epigen\u00e8tica i impacte biol\u00f2gic).<\/p>\n\n\n\n

Del laboratori al taulell de la farm\u00e0cia<\/strong><\/h2>\n\n\n\n

En darrer lloc, va intervenir el farmac\u00e8utic comunitari Miquel Serra <\/strong>per explicar el canvi d\u2019enfoc en la recomanaci\u00f3 d\u2019un producte. En aquest senti, va dir que \u201cel canvi no est\u00e0 nom\u00e9s en el producte, est\u00e0 en el punt de partida i en com s\u2019interpreta al pacient des de la farm\u00e0cia comunit\u00e0ria\u201d<\/strong>. Serra va indicar que un farmac\u00e8utic ha d\u2019identificar la necessitat real del pacient, traduir el mecanisme en un benefici clar, adaptar la recomanaci\u00f3 al context real i prioritzar all\u00f2 m\u00e9s necessari per obtenir un resultat. A la vegada, va recomanar traduir la innovaci\u00f3 al llenguatge del client <\/strong>perqu\u00e8 \u201cel farmac\u00e8utic fa cada dia el que cap investigador pot fer, que \u00e9s agafar conceptes complexos i traduir-los de forma clara i \u00fatil pel pacient\u201d.<\/strong><\/p>\n\n\n\n

\"Miquel<\/a>
Miquel Serra en un moment de la seva exposici\u00f3.<\/figcaption><\/figure>\n\n\n\n

Per altra banda, va diferenciar la interpretaci\u00f3 de la pell del pacient en tres nivells per poder identificar la necessitat real i decidir la recomanaci\u00f3 m\u00e9s adequada. Aix\u00ed doncs, va fer refer\u00e8ncia a la demanda expl\u00edcita, la lectura professional i el mecanisme subjacent. El farmac\u00e8utic va destacar el rol del farmac\u00e8utic comunitari com a referent que aporta \u201cclaredat, seguretat i resultats reals\u201d<\/strong>.<\/p>\n\n\n\n

Per tancar la sessi\u00f3, el farmac\u00e8utic va compartir una darrera reflexi\u00f3 entorn de l\u2019epigen\u00e8tica, que \u201cens ha ensenyat que el dest\u00ed gen\u00e8tic no \u00e9s una sent\u00e8ncia perqu\u00e8 l\u2019entorn i les intervencions actives poden modificar com i quan envelleixen les nostres c\u00e8l\u00b7lules\u201d.<\/strong><\/p>\n\n\n\n

Amb el patrocini de:<\/strong><\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

El passat 18 de juny, el Col\u00b7legi de Farmac\u00e8utics de Barcelona (COFB) va organitzar el darrer F\u00f2rum Dermoexpert \u201cEpigen\u00e8tica: noves bases per a la dermocosm\u00e8tica\u201d, amb el patrocini d\u2019HD Cosmetic Efficiency. El F\u00f2rum va ser impartit per Regina Pall\u00e1s, farmac\u00e8utica i directora d\u2019I+D de Dermogalenic Experts; Jose Lu\u00eds Mullor, bi\u00f2leg, […]<\/p>\n","protected":false},"author":3,"featured_media":85109,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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