{"id":77635,"date":"2011-11-29T15:41:00","date_gmt":"2011-11-29T15:41:00","guid":{"rendered":"https:\/\/novaorg.cofb.net\/2011\/11\/29\/un-estudi-descarta-que-lus-cronic-domeprazol-i-similars-i-de-determinats-antidepressius-incrementin-substancialment-el-risc-de-fractura-de-maluc\/"},"modified":"2011-11-29T15:41:00","modified_gmt":"2011-11-29T15:41:00","slug":"un-estudi-descarta-que-lus-cronic-domeprazol-i-similars-i-de-determinats-antidepressius-incrementin-substancialment-el-risc-de-fractura-de-maluc","status":"publish","type":"post","link":"https:\/\/www.cofb.org\/ca\/2011\/11\/29\/un-estudi-descarta-que-lus-cronic-domeprazol-i-similars-i-de-determinats-antidepressius-incrementin-substancialment-el-risc-de-fractura-de-maluc\/","title":{"rendered":"Un estudi descarta que l’\u00fas cr\u00f2nic d’omeprazol i similars i de determinats antidepressius incrementin substancialment el risc de fractura de maluc"},"content":{"rendered":"

\u00a0<\/p>\n

\u00a0Barcelona, novembre de 2011.- Un estudi, dut a terme a la<\/span>\u00a0<\/span>Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed<\/strong>, i becat pel<\/span>\u00a0<\/span>Col\u2022legi de Farmac\u00e8utics de Barcelona<\/strong>, ha concl\u00f2s que els inhibidors de la bomba de protons i els antidepressius inhibidors selectius de la captaci\u00f3 de serotonina no s\u00f3n determinants majors del risc de fractura de maluc i\/o pelvis al nostre entorn.<\/span><\/p>\n

Per dur a terme l\u2019estudi es va realitzar un estudi de casos i controls de base hospital\u00e0ria, que va incloure malalts, de 50 a 95 anys, atesos al servei d\u2019urg\u00e8ncies de l\u2019hospital per fractura de maluc i\/o pelvis per fragilitat \u00f2ssia i es va valorar l\u2019exposici\u00f3 farmacol\u00f2gica de la poblaci\u00f3 estudiada en els 10 darrers anys, amb especial \u00e8mfasi sobre inhibidors de la bomba de protons, inhibidors selectius de la recaptaci\u00f3 de serotonina i glitazones. Tanmateix, es va explotar el risc de fractures patol\u00f2giques associat a l\u2019\u00fas prolongat de bifosfonats.<\/p>\n

El context i el perqu\u00e8 de l\u2019estudi
Les fractures per fragilitat \u00f2ssia, que s\u00f3n les que es produeixen per traumatismes de poca energia, constitueixen un important problema de salut p\u00fablica que implica una elevada taxa de morbimortalitat i suposa una \u00e0mplia utilitzaci\u00f3 de recursos sanitaris.<\/p>\n

Diferents estudis apunten que determinats f\u00e0rmacs poden afavorir l\u2019aparici\u00f3 de fractures, ja que poden incrementar la freq\u00fc\u00e8ncia de caigudes i les seves conseq\u00fc\u00e8ncies, o disminuir la massa \u00f2ssia pels seus efectes sobre el metabolisme ossi. Entre els f\u00e0rmacs que s\u2019associen de forma significativa a un augment de risc de les caigudes i com a conseq\u00fc\u00e8ncia de fractures, es troben els hipnosedants, antidepressius, antipsic\u00f2tics i opioides.<\/p>\n

Recentment s\u2019han identificat nous f\u00e0rmacs o grups de f\u00e0rmacs com a factors de risc de fractures a conseq\u00fc\u00e8ncia d\u2019una alteraci\u00f3 del metabolisme mineral ossi: les glitazones, els antidepressius inhibidors selectius de la recaptaci\u00f3 de la serotonina (ISRS), els inhibidors de la bomba de protons (IBP) i l\u2019\u00fas perllongat de bifosfonats. Per aquest motiu, des de la Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed es va decidir engegar un estudi, becat pel Col\u2022legi de Farmac\u00e8utics de Barcelona, per avaluar la relaci\u00f3 entre l\u2019exposici\u00f3 cr\u00f2nica a f\u00e0rmacs, amb \u00e8mfasi especial en aquest darrer grup de medicaments (glitazones, ISRS, IBP i bifosfonats), i el risc de fractures de maluc o pelvis per fragilitat \u00f2ssia.<\/p>\n

Les conclusions de l\u2019estudi indiquen que la prevalen\u00e7a d\u2019\u00fas d\u2019inhibidors de la bomba de protons va ser de m\u00e9s del 50% de la poblaci\u00f3 estudiada, per\u00f2 que no hi ha associacions significatives rellevants entre el risc de fractura i exposicions a inhibidors de la bomba de protons. De manera semblant, els antidepressius inhibidors selectius de la recaptaci\u00f3 de serotonina van tenir una prevalen\u00e7a d\u2019\u00fas en torn al 20% de la poblaci\u00f3 estudiada, per\u00f2 no es van associar a increments de risc independentment de la seva durada i del moment de l\u2019exposici\u00f3. Pel que fa a les glitazones, s\u2019ha contrastat que la seva utilitzaci\u00f3 en el nostre entorn \u00e9s pr\u00e0cticament inexistent. Quant als bifosfonats, no es va observar cap associaci\u00f3 de risc, si b\u00e9 \u00e9s important destacar que es van trobar una baixa prevalen\u00e7a d\u2019utilitzaci\u00f3 en durades superiors a 5 anys, pel que no \u00e9s possible detectar associacions significatives de risc de fractures a llarg termini.<\/p>\n

Autors de l\u2019estudi \u201cRisc de fractures associat a medicaments: estudi de casos i controls\u201d: Maria Queralt Gorgas Torner, Irene L\u00f3pez Rico, Servei de Farm\u00e0cia de la Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed.<\/p>\n

Per a m\u00e9s informaci\u00f3:
Departament de Comunicaci\u00f3\u00a0
Col\u2022legi de Farmac\u00e8utics de Barcelona
Tfn: 93 244 07 28\/18 \u2013 E-mail:\u00a0premsa@cofb.net<\/a><\/p>\n

\u00a0\u00a0Barcelona, novembre de 2011.- Un estudi, dut a terme a la\u00a0Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed, i becat pel\u00a0Col\u2022legi de Farmac\u00e8utics de Barcelona, ha concl\u00f2s que els inhibidors de la bomba de protons i els antidepressius inhibidors selectius de la captaci\u00f3 de serotonina no s\u00f3n determinants majors del risc de fractura de maluc i\/o pelvis al nostre entorn.Per dur a terme l\u2019estudi es va realitzar un estudi de casos i controls de base hospital\u00e0ria, que va incloure malalts, de 50 a 95 anys, atesos al servei d\u2019urg\u00e8ncies de l\u2019hospital per fractura de maluc i\/o pelvis per fragilitat \u00f2ssia i es va valorar l\u2019exposici\u00f3 farmacol\u00f2gica de la poblaci\u00f3 estudiada en els 10 darrers anys, amb especial \u00e8mfasi sobre inhibidors de la bomba de protons, inhibidors selectius de la recaptaci\u00f3 de serotonina i glitazones. Tanmateix, es va explotar el risc de fractures patol\u00f2giques associat a l\u2019\u00fas prolongat de bifosfonats.El context i el perqu\u00e8 de l\u2019estudiLes fractures per fragilitat \u00f2ssia, que s\u00f3n les que es produeixen per traumatismes de poca energia, constitueixen un important problema de salut p\u00fablica que implica una elevada taxa de morbimortalitat i suposa una \u00e0mplia utilitzaci\u00f3 de recursos sanitaris.Diferents estudis apunten que determinats f\u00e0rmacs poden afavorir l\u2019aparici\u00f3 de fractures, ja que poden incrementar la freq\u00fc\u00e8ncia de caigudes i les seves conseq\u00fc\u00e8ncies, o disminuir la massa \u00f2ssia pels seus efectes sobre el metabolisme ossi. Entre els f\u00e0rmacs que s\u2019associen de forma significativa a un augment de risc de les caigudes i com a conseq\u00fc\u00e8ncia de fractures, es troben els hipnosedants, antidepressius, antipsic\u00f2tics i opioides.Recentment s\u2019han identificat nous f\u00e0rmacs o grups de f\u00e0rmacs com a factors de risc de fractures a conseq\u00fc\u00e8ncia d\u2019una alteraci\u00f3 del metabolisme mineral ossi: les glitazones, els antidepressius inhibidors selectius de la recaptaci\u00f3 de la serotonina (ISRS), els inhibidors de la bomba de protons (IBP) i l\u2019\u00fas perllongat de bifosfonats. Per aquest motiu, des de la Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed es va decidir engegar un estudi, becat pel Col\u2022legi de Farmac\u00e8utics de Barcelona, per avaluar la relaci\u00f3 entre l\u2019exposici\u00f3 cr\u00f2nica a f\u00e0rmacs, amb \u00e8mfasi especial en aquest darrer grup de medicaments (glitazones, ISRS, IBP i bifosfonats), i el risc de fractures de maluc o pelvis per fragilitat \u00f2ssia.Les conclusions de l\u2019estudi indiquen que la prevalen\u00e7a d\u2019\u00fas d\u2019inhibidors de la bomba de protons va ser de m\u00e9s del 50% de la poblaci\u00f3 estudiada, per\u00f2 que no hi ha associacions significatives rellevants entre el risc de fractura i exposicions a inhibidors de la bomba de protons. De manera semblant, els antidepressius inhibidors selectius de la recaptaci\u00f3 de serotonina van tenir una prevalen\u00e7a d\u2019\u00fas en torn al 20% de la poblaci\u00f3 estudiada, per\u00f2 no es van associar a increments de risc independentment de la seva durada i del moment de l\u2019exposici\u00f3. Pel que fa a les glitazones, s\u2019ha contrastat que la seva utilitzaci\u00f3 en el nostre entorn \u00e9s pr\u00e0cticament inexistent. Quant als bifosfonats, no es va observar cap associaci\u00f3 de risc, si b\u00e9 \u00e9s important destacar que es van trobar una baixa prevalen\u00e7a d\u2019utilitzaci\u00f3 en durades superiors a 5 anys, pel que no \u00e9s possible detectar associacions significatives de risc de fractures a llarg termini.Autors de l\u2019estudi \u201cRisc de fractures associat a medicaments: estudi de casos i controls\u201d: Maria Queralt Gorgas Torner, Irene L\u00f3pez Rico, Servei de Farm\u00e0cia de la Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed.Per a m\u00e9s informaci\u00f3:Departament de Comunicaci\u00f3\u00a0Col\u2022legi de Farmac\u00e8utics de BarcelonaTfn: 93 244 07 28\/18 \u2013 E-mail:\u00a0premsa@cofb.net\u00a0\u00a0COFB.ORG<\/p>\n","protected":false},"excerpt":{"rendered":"

\u00a0 \u00a0Barcelona, novembre de 2011.- Un estudi, dut a terme a la\u00a0Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed, i becat pel\u00a0Col\u2022legi de Farmac\u00e8utics de Barcelona, ha concl\u00f2s que els inhibidors de la bomba de protons i els antidepressius inhibidors selectius de la captaci\u00f3 de serotonina no s\u00f3n determinants majors del risc de fractura […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1060,1066],"tags":[],"class_list":["post-77635","post","type-post","status-publish","format-standard","hentry","category-notes-premsa","category-sense-categoria-ca"],"yoast_head":"\nUn estudi descarta que l'\u00fas cr\u00f2nic d'omeprazol i similars i de determinats antidepressius incrementin substancialment el risc de fractura de maluc - 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