El codirector de la plataforma de cribratge de mol\u00e8cules antivirals del CNB-CSIC ofereix les claus d’una xarxa de recerca que ha analitzat ja 2.400 f\u00e0rmacs de reposicionament cl\u00ednic i m\u00e9s de 8.000 compostos experimentals des de mar\u00e7 de 2020 en la cerca de nous f\u00e0rmacs<\/li>\n<\/ul>\n\nMadrid, 25 de mar\u00e7. <\/em>Urtzi Garaigorta de Dios, investigador del Departament de Biologia Cel\u00b7lular i Molecular del Centro Nacional de Biotecnolog\u00eda (CNB-CSIC), va presentar a Infarma Madrid 2022 el treball desenvolupat dins de la Plataforma de cribratge de mol\u00e8cules antivirals enfront de SARS-CoV-2 i altres virus, una iniciativa llan\u00e7ada el 2020 dins del del Consejo Superior de Investigaciones Cient\u00edficas (CSIC) que s’ha convertit en una resposta cient\u00edfica i col\u00b7laborativa de treball en xarxa.<\/p>\nEs tracta d’un projecte que agrupa a prop de 300 investigadors, entre t\u00e8cnics, investigadors pre i post doctorals, aix\u00ed com investigadors s\u00e8nior, distribu\u00efts en 19 grups de recerca repartits en nou centres, a m\u00e9s de tres centres de s\u00edntesi qu\u00edmica, tots pertanyents al CSIC. El seu objectiu \u00e9s buscar medicaments contra la infecci\u00f3 pel coronavirus, a trav\u00e9s del cribratge i identificaci\u00f3 de milers de compostos, ja es tracti de nous antivirals o del reposicionament de mol\u00e8cules d’\u00fas cl\u00ednic ja existents mitjan\u00e7ant l’optimitzaci\u00f3 de candidats i la caracteritzaci\u00f3 antiviral.<\/p>\n
El codirector i cocoordinador de les Plataformas de B\u00fasqueda de Antivirales del CNB i de la PTI+ Salud Global del CSIC va avan\u00e7ar les estrat\u00e8gies de desenvolupament de f\u00e0rmacs antivirals que segueixen a trav\u00e9s d’assajos biol\u00f2gics i fenot\u00edpics o quimioteques de compostos per aconseguir candidats antivirals i composts cap de s\u00e8rie, a m\u00e9s d’exposar les perspectives a mitj\u00e0 i llarg termini obertes per aquesta mena de plataformes que estan permetent abordar tant el reposicionament de compostos d’\u00fas cl\u00ednic com l’exploraci\u00f3 de nous compostos antivirals. Aquests f\u00e0rmacs permeten reduir la c\u00e0rrega viral i limitar, en conseq\u00fc\u00e8ncia, la propagaci\u00f3 del virus, amb la finalitat d’evitar el desenvolupament de la malaltia greu i estar aix\u00ed millor preparats davant futures pand\u00e8mies. Entre aquests compostos estan ja aprovats tenofovir, molnupiravir (Lagrevio), sotrovimab (Xevudy), sofosbuvir (Sovaldi) o nirmatrelvir-ritonavir (Paxlovid), entre altres.<\/p>\n
Durant la seva intervenci\u00f3, l’investigador va advertir que les pand\u00e8mies virals s\u00f3n cada vegada m\u00e9s freq\u00fcents. A m\u00e9s de la incid\u00e8ncia del tr\u00e0nsit aeri en la velocitat de transmissi\u00f3 dels virus, \u201cuna de les raons \u00e9s l’escalfament global, l’activitat humana fa que augmenti la temperatura global i provoca canvis ecol\u00f2gics i la colonitzaci\u00f3 de nous n\u00ednxols\u201d, va explicar dimecres passat.<\/p>\n
Davant aquest problema, al mar\u00e7 de 2020 es va posar en marxa la nova plataforma de cribratge que busca donar una visi\u00f3 global davant els nous reptes de salut mundial. Fruit d’aquesta xarxa de col\u00b7laboraci\u00f3 \u00e9s la r\u00e0pida resposta obtinguda per a recaptar una biblioteca de compostos. En menys d’un mes, van rebre 5.000 compostos per a comen\u00e7ar a testar. En total, han avaluat 2.400 f\u00e0rmacs de reposicionament i 8.000 compostos experimentals.<\/p>\n
El 2021, el CSIC va ampliar la plataforma amb la finalitat de treballar en el cribratge antiviral fins a integrar a 300 investigadors. Estructurats en quatre grups de treball (s\u00edntesi qu\u00edmica de compostos, assajos biol\u00f2gics basats en diana, assajos fenot\u00edpics de models i assajos en animals), mant\u00e9 una relaci\u00f3 molt estreta amb la ind\u00fastria farmac\u00e8utica i aliment\u00e0ria, interessada a desenvolupar compostos.<\/p>\n
\u201cL’objectiu \u00e9s estar preparats per al que vindr\u00e0. El SARS-CoV-2 no ser\u00e0 el que ens preocupi en el futur, hem d’observar i estudiar la salut animal, no nom\u00e9s la humana, en un concepte d’una sola salut, ja que ens estan arribant nous virus\u201d, va advertir.<\/p>\n
En els \u00faltims anys, han sorgit virus que no tenien incid\u00e8ncia a Espanya, per\u00f2 que s\u00f3n ja end\u00e8mics al nostre pa\u00eds, com el virus del Nil, que s’ha convertit ja en un problema de salut p\u00fablica. Altres pat\u00f2gens com el virus causant de la febre hemorr\u00e0gica de Crimea-Congo i la grip avi\u00e0ria poden ser tamb\u00e9 un problema al futur, per la qual cosa l’investigador va fer una crida sobre la necessitat de mantenir la vigil\u00e0ncia en la salut humana, animal i mediambiental.<\/p>\n
\u00a0El codirector de la plataforma de cribratge de mol\u00e8cules antivirals del CNB-CSIC ofereix les claus d’una xarxa de recerca que ha analitzat ja 2.400 f\u00e0rmacs de reposicionament cl\u00ednic i m\u00e9s de 8.000 compostos experimentals des de mar\u00e7 de 2020 en la cerca de nous f\u00e0rmacs<\/p>\n
Madrid, 25 de mar\u00e7. Urtzi Garaigorta de Dios, investigador del Departament de Biologia Cel\u00b7lular i Molecular del Centro Nacional de Biotecnolog\u00eda (CNB-CSIC), va presentar a Infarma Madrid 2022 el treball desenvolupat dins de la Plataforma de cribratge de mol\u00e8cules antivirals enfront de SARS-CoV-2 i altres virus, una iniciativa llan\u00e7ada el 2020 dins del del Consejo Superior de Investigaciones Cient\u00edficas (CSIC) que s’ha convertit en una resposta cient\u00edfica i col\u00b7laborativa de treball en xarxa.<\/p>\n
Es tracta d’un projecte que agrupa a prop de 300 investigadors, entre t\u00e8cnics, investigadors pre i post doctorals, aix\u00ed com investigadors s\u00e8nior, distribu\u00efts en 19 grups de recerca repartits en nou centres, a m\u00e9s de tres centres de s\u00edntesi qu\u00edmica, tots pertanyents al CSIC. El seu objectiu \u00e9s buscar medicaments contra la infecci\u00f3 pel coronavirus, a trav\u00e9s del cribratge i identificaci\u00f3 de milers de compostos, ja es tracti de nous antivirals o del reposicionament de mol\u00e8cules d’\u00fas cl\u00ednic ja existents mitjan\u00e7ant l’optimitzaci\u00f3 de candidats i la caracteritzaci\u00f3 antiviral.<\/p>\n
El codirector i cocoordinador de les Plataformas de B\u00fasqueda de Antivirales del CNB i de la PTI+ Salud Global del CSIC va avan\u00e7ar les estrat\u00e8gies de desenvolupament de f\u00e0rmacs antivirals que segueixen a trav\u00e9s d’assajos biol\u00f2gics i fenot\u00edpics o quimioteques de compostos per aconseguir candidats antivirals i composts cap de s\u00e8rie, a m\u00e9s d’exposar les perspectives a mitj\u00e0 i llarg termini obertes per aquesta mena de plataformes que estan permetent abordar tant el reposicionament de compostos d’\u00fas cl\u00ednic com l’exploraci\u00f3 de nous compostos antivirals. Aquests f\u00e0rmacs permeten reduir la c\u00e0rrega viral i limitar, en conseq\u00fc\u00e8ncia, la propagaci\u00f3 del virus, amb la finalitat d’evitar el desenvolupament de la malaltia greu i estar aix\u00ed millor preparats davant futures pand\u00e8mies. Entre aquests compostos estan ja aprovats tenofovir, molnupiravir (Lagrevio), sotrovimab (Xevudy), sofosbuvir (Sovaldi) o nirmatrelvir-ritonavir (Paxlovid), entre altres.<\/p>\n
Durant la seva intervenci\u00f3, l’investigador va advertir que les pand\u00e8mies virals s\u00f3n cada vegada m\u00e9s freq\u00fcents. A m\u00e9s de la incid\u00e8ncia del tr\u00e0nsit aeri en la velocitat de transmissi\u00f3 dels virus, \u201cuna de les raons \u00e9s l’escalfament global, l’activitat humana fa que augmenti la temperatura global i provoca canvis ecol\u00f2gics i la colonitzaci\u00f3 de nous n\u00ednxols\u201d, va explicar dimecres passat.<\/p>\n
Davant aquest problema, al mar\u00e7 de 2020 es va posar en marxa la nova plataforma de cribratge que busca donar una visi\u00f3 global davant els nous reptes de salut mundial. Fruit d’aquesta xarxa de col\u00b7laboraci\u00f3 \u00e9s la r\u00e0pida resposta obtinguda per a recaptar una biblioteca de compostos. En menys d’un mes, van rebre 5.000 compostos per a comen\u00e7ar a testar. En total, han avaluat 2.400 f\u00e0rmacs de reposicionament i 8.000 compostos experimentals.<\/p>\n
El 2021, el CSIC va ampliar la plataforma amb la finalitat de treballar en el cribratge antiviral fins a integrar a 300 investigadors. Estructurats en quatre grups de treball (s\u00edntesi qu\u00edmica de compostos, assajos biol\u00f2gics basats en diana, assajos fenot\u00edpics de models i assajos en animals), mant\u00e9 una relaci\u00f3 molt estreta amb la ind\u00fastria farmac\u00e8utica i aliment\u00e0ria, interessada a desenvolupar compostos.<\/p>\n
\u201cL’objectiu \u00e9s estar preparats per al que vindr\u00e0. El SARS-CoV-2 no ser\u00e0 el que ens preocupi en el futur, hem d’observar i estudiar la salut animal, no nom\u00e9s la humana, en un concepte d’una sola salut, ja que ens estan arribant nous virus\u201d, va advertir.<\/p>\n
En els \u00faltims anys, han sorgit virus que no tenien incid\u00e8ncia a Espanya, per\u00f2 que s\u00f3n ja end\u00e8mics al nostre pa\u00eds, com el virus del Nil, que s’ha convertit ja en un problema de salut p\u00fablica. Altres pat\u00f2gens com el virus causant de la febre hemorr\u00e0gica de Crimea-Congo i la grip avi\u00e0ria poden ser tamb\u00e9 un problema al futur, per la qual cosa l’investigador va fer una crida sobre la necessitat de mantenir la vigil\u00e0ncia en la salut humana, animal i mediambiental.\u00a0\u00a0COFB.ORG<\/p>\n","protected":false},"excerpt":{"rendered":"
\u00a0 El codirector de la plataforma de cribratge de mol\u00e8cules antivirals del CNB-CSIC ofereix les claus d’una xarxa de recerca que ha analitzat ja 2.400 f\u00e0rmacs de reposicionament cl\u00ednic i m\u00e9s de 8.000 compostos experimentals des de mar\u00e7 de 2020 en la cerca de nous f\u00e0rmacs Madrid, 25 de mar\u00e7. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1060,1066],"tags":[],"class_list":["post-76998","post","type-post","status-publish","format-standard","hentry","category-notes-premsa","category-sense-categoria-ca"],"yoast_head":"\n
Urtzi Garaigorta: "Les pand\u00e8mies virals seran cada vegada m\u00e9s freq\u00fcents i cal estar preparats" - Col\u00b7legi de Farmac\u00e8utics de Barcelona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/novaorg.cofb.net\/2022\/03\/25\/urtzi-garaigorta-les-pandemies-virals-seran-cada-vegada-mes-frequents-i-cal-estar-preparats\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Urtzi Garaigorta: "Les pand\u00e8mies virals seran cada vegada m\u00e9s freq\u00fcents i cal estar preparats" - Col\u00b7legi de Farmac\u00e8utics de Barcelona\" \/>\n<meta property=\"og:description\" content=\"\u00a0 El codirector de la plataforma de cribratge de mol\u00e8cules antivirals del CNB-CSIC ofereix les claus d’una xarxa de recerca que ha analitzat ja 2.400 f\u00e0rmacs de reposicionament cl\u00ednic i m\u00e9s de 8.000 compostos experimentals des de mar\u00e7 de 2020 en la cerca de nous f\u00e0rmacs Madrid, 25 de mar\u00e7. 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