{"id":64080,"date":"2022-07-12T13:46:00","date_gmt":"2022-07-12T11:46:00","guid":{"rendered":"https:\/\/blog.cofb.cat\/?p=64080"},"modified":"2023-10-09T14:20:11","modified_gmt":"2023-10-09T14:20:11","slug":"com-seran-els-farmacs-del-futur-nova-tertulia-dactualitat-al-cofb","status":"publish","type":"post","link":"https:\/\/www.cofb.org\/ca\/2022\/07\/12\/com-seran-els-farmacs-del-futur-nova-tertulia-dactualitat-al-cofb\/","title":{"rendered":"Com seran els f\u00e0rmacs del futur? Nova tert\u00falia d’actualitat al COFB"},"content":{"rendered":"\n

El passat 16 de juny<\/strong> el Col\u00b7legi de Farmac\u00e8utics de Barcelona<\/strong> va acollir una nova edici\u00f3 de les tert\u00falies d’actualitat sota el t\u00edtol “Com seran els f\u00e0rmacs del futur?”<\/strong>. La confer\u00e8ncia va anar a c\u00e0rrec de Rafael Maldonado<\/strong>, investigador i catedr\u00e0tic del Departament de Ci\u00e8ncies Experimentals i de la Salut de la Universitat Pompeu Fabra. Aina Surroca<\/strong>, secret\u00e0ria de la Junta de Govern del COFB i responsable de la Comissi\u00f3 Delegada de Formaci\u00f3, va moderar la sessi\u00f3.<\/p>\n\n\n\n

\"
Rafael Maldonado, investigador i catedr\u00e0tic del Departament de Ci\u00e8ncies Experimentals i de la Salut de la Universitat Pompeu Fabra, i Aina Surroca, secret\u00e0ria de la Junta de Govern del COFB i responsable de la Comissi\u00f3 Delegada de Formaci\u00f3, a l’inici de la sessi\u00f3.<\/figcaption><\/figure>\n\n\n\n

L’objectiu <\/strong>d’aquesta tert\u00falia va ser con\u00e8ixer m\u00e9s sobre l’evoluci\u00f3<\/strong> i funcionament<\/strong> de nous f\u00e0rmacs biol\u00f2gics<\/strong> com els anticossos monoclonals<\/strong> o les ter\u00e0pies basades en ARN.<\/strong>
<\/p>\n\n\n\n

Quins avantatges ofereixen els f\u00e0rmacs biol\u00f2gics?<\/strong><\/h2>\n\n\n\n

Per comen\u00e7ar, Maldonado va resumir les tend\u00e8ncies dels medicaments del futur en tres idees clau: m\u00e9s precisos<\/strong>, m\u00e9s efica\u00e7os<\/strong> i amb menys efectes secundaris<\/strong>. I segons el seu criteri “aquest futur ja ha comen\u00e7at” destacant que “actualment s’est\u00e0 avan\u00e7ant cap a uns f\u00e0rmacs totalment diferents del que hem vist i hem tingut fins ara”. Respecte al que tothom coneix com a f\u00e0rmacs tradicionals, que ens han perm\u00e8s tractar durant anys una gran quantitat de malalties, l’investigador va assenyalar que “ara han arribat per quedar-se, i amb unes enormes perspectives de futur, f\u00e0rmacs biol\u00f2gics<\/strong> com els anticossos monoclonals o els portadors d’ARN<\/strong>” <\/p>\n\n\n\n

\"El
El Dr. Rafael Maldonado en un moment de la seva intervenci\u00f3 a la Tert\u00falia d’Actualitat: “Com seran els f\u00e0rmacs del futur?”.<\/figcaption><\/figure>\n\n\n\n

Amb relaci\u00f3 als beneficis<\/strong> i avantatges<\/strong> dels anticossos monoclonals<\/strong>, va explicar que “s\u00f3n uns f\u00e0rmacs que no tenen metab\u00f2lits t\u00f2xics<\/strong>, tenen una farmacocin\u00e8tica ideal per a la prevenci\u00f3 de malalties cr\u00f2niques<\/strong>, no hi ha toxicitat fora de la diana<\/strong>, i la tolerabilitat general acostuma a ser bona<\/strong>“. <\/p>\n\n\n\n

En quant als avantatges <\/strong>de la ter\u00e0pia ARN<\/strong> s\u00f3n “la major selecci\u00f3 de dianes no susceptibles als efectes farmacol\u00f2gics<\/strong>, la producci\u00f3 r\u00e0pida<\/strong> del f\u00e0rmac, l’efecte a llarg termini<\/strong>, la utilitat per malalties poc comunes<\/strong> i el nul risc de genotoxicitat<\/strong>“. Malgrat la seva gran pres\u00e8ncia actual arran l’emerg\u00e8ncia sanit\u00e0ria de la COVID-19<\/strong>, va aclarir que “el descobriment d’aquest tipus de ter\u00e0pia no \u00e9s novetat. El descobriment de l’ARN missatger remunta a l’any 1960 i el primer f\u00e0rmac<\/strong> basat en ARN va ser aprovat l’any 1998<\/strong>“.
<\/p>\n\n\n\n

Els f\u00e0rmacs biol\u00f2gics fora de la farm\u00e0cia hospital\u00e0ria<\/strong><\/h2>\n\n\n\n

Maldonado<\/strong> va compartir que “personalment no veig viable que el circuit d’aquests f\u00e0rmacs nom\u00e9s es dugui a terme a trav\u00e9s de la farm\u00e0cia hospital\u00e0ria<\/strong>, ja que aquesta t\u00e9 un gran volum de feina”. Per tant, “en algun moment s’haur\u00e0 de donar protagonisme a la farm\u00e0cia no hospital\u00e0ria. Independentment de qui porti el control, aquests f\u00e0rmacs han d’arribar al conjunt de la poblaci\u00f3”<\/strong>. En la seva opini\u00f3 “la farm\u00e0cia comunit\u00e0ria est\u00e0 perfectament capacitada per realitzar aquest control, propiciant, a m\u00e9s, que aquests f\u00e0rmacs siguin m\u00e9s accessibles pels ciutadans”.<\/strong> <\/p>\n\n\n

\n\n\n

Els f\u00e0rmacs biol\u00f2gics al mercat actual<\/strong><\/h3>\n\n\n\n

Descobrir i desenvolupar f\u00e0rmacs<\/strong> vol dir seguir processos llargs<\/strong>. Normalment, transcorren de deu a quinze anys<\/strong> entre que comen\u00e7a la investigaci\u00f3 <\/strong>i el llan\u00e7ament al mercat<\/strong> del medicament, m\u00e9s els sis i vuit anys que passen entre els assaigs cl\u00ednics de fase I i el llan\u00e7ament.<\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

El Dr. Maldonado<\/strong> va indicar que dels 10 f\u00e0rmacs m\u00e9s venuts <\/strong>en tot el m\u00f3n durant l’any 2021<\/strong>, 6 s\u00f3n f\u00e0rmacs biol\u00f2gics<\/strong>. Comirnaty i Spikevax basats en ARNm, i Humira, Keytruda, Stelara i Opdivo anticossos monoclonals.<\/p> <\/div>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

El passat 16 de juny el Col\u00b7legi de Farmac\u00e8utics de Barcelona va acollir una nova edici\u00f3 de les tert\u00falies d’actualitat sota el t\u00edtol “Com seran els f\u00e0rmacs del futur?”. La confer\u00e8ncia va anar a c\u00e0rrec de Rafael Maldonado, investigador i catedr\u00e0tic del Departament de Ci\u00e8ncies Experimentals i de la Salut […]<\/p>\n","protected":false},"author":1,"featured_media":67872,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[23,57],"tags":[847,848,849,850,18,851,69,480,54,713,852,70,853,44,147,854,855,856,857,752,140],"class_list":["post-64080","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-destacats","category-mon-collegial","tag-anticossos-monoclonals","tag-arn","tag-arnm","tag-beneficis","tag-cofb","tag-evolucio","tag-farmacia-comunitaria","tag-farmacia-hospitalaria","tag-farmacs","tag-farmacs-biologics","tag-farmacs-del-futur","tag-formacio","tag-futur","tag-malaltia","tag-medicament","tag-mercat","tag-sessio","tag-sistema-nervios-central","tag-snc","tag-terapia","tag-tertulia-dactualitat"],"yoast_head":"\nCom seran els f\u00e0rmacs del futur? 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